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Novel APC-like properties of human NK cells directly regulate T cell activation.

Abstract:

Initiation of the adaptive immune response is dependent on the priming of naive T cells by APCs. Proteomic analysis of unactivated and activated human NK cell membrane-enriched fractions demonstrated that activated NK cells can efficiently stimulate T cells, since they upregulate MHC class II molecules and multiple ligands for TCR costimulatory molecules. Furthermore, by manipulating antigen administration, we show that NK cells possess multiple independent unique pathways for antigen uptake....

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Publisher copy:
10.1172/jci22787

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Journal:
Journal of clinical investigation More from this journal
Volume:
114
Issue:
11
Pages:
1612-1623
Publication date:
2004-12-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Language:
English
Keywords:
Pubs id:
pubs:482830
UUID:
uuid:6819f4a8-07fc-4dd9-9799-9aed0328a12e
Local pid:
pubs:482830
Source identifiers:
482830
Deposit date:
2014-09-11

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