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Journal article

Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry.

Abstract:
High-throughput screening of an array of biphenylmethylamines synthesised by high-throughput solid-phase chemistry resulted in the identification of compounds with high-affinity for the 5-ht5A receptor. The structure-activity relationship within this series and further array synthesis led to the identification of the biphenylmethylamine derivative 11, a potent and selective 5-ht5A receptor antagonist.
Publication status:
Published

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Publisher copy:
10.1016/j.bmcl.2005.06.024

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
Bioorganic and medicinal chemistry letters More from this journal
Volume:
15
Issue:
18
Pages:
4014-4018
Publication date:
2005-09-01
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
Language:
English
Keywords:
Pubs id:
pubs:33158
UUID:
uuid:6816c807-aab2-41b2-9ae5-053b64a3c6ca
Local pid:
pubs:33158
Source identifiers:
33158
Deposit date:
2012-12-19

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