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T-B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in Bcl-2-deficient mice.

Abstract:

Bcl-2 expression is tightly regulated during lymphocyte development. Mature lymphocytes in Bcl-2-deficient mice show accelerated spontaneous apoptosis in vivo and in vitro. Stimulation of Bcl-2-deficient lymphocytes by anti-CD3 antibody inhibited the spontaneous apoptosis not only in T cells but also in B cells. The rescue of B cells was dependent on the presence of T cells, mainly through CD40L and interleukin (IL)-4. Furthermore, we generated Bcl-2-deficient mice transgenic for a T cell rec...

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Publisher copy:
10.1084/jem.182.4.1101

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
The Journal of experimental medicine
Volume:
182
Issue:
4
Pages:
1101-1109
Publication date:
1995-10-29
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:6815a8f5-f757-40ba-8650-8adf8d08f7a8
Source identifiers:
483518
Local pid:
pubs:483518

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