Journal article
Doxorubicin-induced DNA damage causes extensive ubiquitination of ribosomal proteins associated with a decrease in protein translation
- Abstract:
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Protein post-translational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have been shown to be essential in the signalling cascade that coordinates break repair with cell cycle progression. Here, we performed whole-cell quantitative proteomics to identify global changes in protein ubiquitination that are induced by DNA double-strand breaks. In total, we quantified more than 9400 ubiquitin sites and found that the...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 9.0MB)
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- Publisher copy:
- 10.1074/mcp.ra118.000652
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Authors
Funding
Netherlands Organization for Scientific Research
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Basque Country Government
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Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Molecular and Cellular Proteomics Journal website
- Publication date:
- 2018-02-08
- Acceptance date:
- 2018-02-08
- DOI:
- EISSN:
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1535-9484
- ISSN:
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1535-9476
- Pmid:
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29438997
- Source identifiers:
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825598
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:825598
- UUID:
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uuid:680dfc9b-c4f2-4b97-b5a1-5bef9038b5be
- Local pid:
- pubs:825598
- Deposit date:
- 2018-04-12
Terms of use
- Copyright holder:
- American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 American Society for Biochemistry and Molecular Biology. This is the accepted manuscript version of the article. The final version is available online from the American Society for Biochemistry and Molecular Biology at: http://dx.doi.org/10.1074/mcp.ra118.000652
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