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Doxorubicin-induced DNA damage causes extensive ubiquitination of ribosomal proteins associated with a decrease in protein translation

Abstract:

Protein post-translational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have been shown to be essential in the signalling cascade that coordinates break repair with cell cycle progression. Here, we performed whole-cell quantitative proteomics to identify global changes in protein ubiquitination that are induced by DNA double-strand breaks. In total, we quantified more than 9400 ubiquitin sites and found that the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Files:
Publisher copy:
10.1074/mcp.ra118.000652

Authors


García-Santisteban, I More by this author
Warmerdam, DO More by this author
van den Broek, B More by this author
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Netherlands Organization for Scientific Research More from this funder
Basque Country Government More from this funder
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Molecular and Cellular Proteomics Journal website
Publication date:
2018-02-08
Acceptance date:
2018-02-08
DOI:
EISSN:
1535-9484
ISSN:
1535-9476
Pubs id:
pubs:825598
URN:
uri:680dfc9b-c4f2-4b97-b5a1-5bef9038b5be
UUID:
uuid:680dfc9b-c4f2-4b97-b5a1-5bef9038b5be
Local pid:
pubs:825598

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