Risk of gastrointestinal bleeding in patients undergoing total hip or knee replacement compared with matched controls: a nationwide cohort study.

Journal article

OBJECTIVES: Gastrointestinal (GI) bleeding may impose a serious threat in patients undergoing total hip or knee replacement (THR/TKR). The objectives of this study are to evaluate the timing of GI bleeding following THR/TKR and to determine the effect modification by proton pump inhibitor (PPI) use. METHODS: In a nationwide Danish cohort study, we selected all patients with a primary THR/TKR between 1998 and 2007 (n=95,115). Three control subjects without THR/TKR were matched by age, sex, an...

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Authors: Lalmohamed, A; Vestergaard, P; Javaid, M; de Boer, A; Leufkens, H

• Publication status: Published
• Journal: American journal of gastroenterology
• Volume: 108
• Issue: 8
• Pages: 1277-1285
• Publication date: 2013-08-01
• DOI: 10.1038/ajg.2013.108
• EISSN: 1572-0241
• ISSN: 0002-9270
• Language: English
• Keywords: Postoperative Complications; Aged; Cohort Studies; Humans; Risk Factors; Gastrointestinal Hemorrhage; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Female; Incidence; Arthroplasty, Replacement, Knee; Denmark; Risk; Case-Control Studies; Proportional Hazards Models; Arthroplasty, Replacement, Hip