Expression of HLA class I antigens in transporter associated with antigen processing (TAP)-deficient mutant cell lines.

Journal article

Cells lacking expression of the transporter associated with antigen processing (TAP) are deficient in surface HLA class I, yet express reduced levels of HLA-A2 antigen through TAP-independent processing pathways. We have analysed the expression of HLA-A, -B and -C antigens on the 721.174 and T2 TAP-deficient mutant cell lines using a panel of monoclonal antibodies specific for the HLA antigens encoded by the genotype of these cells. Our study has shown the constitutive expression of HLA-Cw1 m...

Expand abstract

Authors: Young, N; Mulder, A; Cerundolo, V; Claas, F; Welsh, K

• Publication status: Published
• Journal: Tissue antigens
• Volume: 52
• Issue: 4
• Pages: 368-373
• Publication date: 1998-10-01
• DOI: 10.1111/j.1399-0039.1998.tb03057.x
• EISSN: 1399-0039
• ISSN: 0001-2815
• Language: English
• Keywords: Animals; Flow Cytometry; Antibodies, Monoclonal; Humans; Alleles; Cell Line; Mice; Major Histocompatibility Complex; Genotype; HLA Antigens; ATP-Binding Cassette Transporters