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Expression of HLA class I antigens in transporter associated with antigen processing (TAP)-deficient mutant cell lines.

Abstract:

Cells lacking expression of the transporter associated with antigen processing (TAP) are deficient in surface HLA class I, yet express reduced levels of HLA-A2 antigen through TAP-independent processing pathways. We have analysed the expression of HLA-A, -B and -C antigens on the 721.174 and T2 TAP-deficient mutant cell lines using a panel of monoclonal antibodies specific for the HLA antigens encoded by the genotype of these cells. Our study has shown the constitutive expression of HLA-Cw1 m...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Tissue antigens More from this journal
Volume:
52
Issue:
4
Pages:
368-373
Publication date:
1998-10-01
DOI:
EISSN:
1399-0039
ISSN:
0001-2815
Language:
English
Keywords:
Pubs id:
pubs:36258
UUID:
uuid:68044eeb-2c1b-45a8-9f0f-da8251ff78c6
Local pid:
pubs:36258
Source identifiers:
36258
Deposit date:
2012-12-19

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