Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: a randomised controlled trial.

Journal article

BACKGROUND: Findings of large randomised trials have shown that lowering LDL cholesterol with statins reduces vascular morbidity and mortality rapidly, but limited evidence exists about the long-term efficacy and safety of statin treatment. The aim of the extended follow-up of the Heart Protection Study (HPS) is to assess long-term efficacy and safety of lowering LDL cholesterol with statins, and here we report cause-specific mortality and major morbidity in the in-trial and post-trial period...

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Authors: Bulbulia, R; Bowman, L; Wallendszus, K; Parish, S; Armitage, J

• Publication status: Published
• Journal: Lancet
• Volume: 378
• Issue: 9808
• Pages: 2013-2020
• Publication date: 2011-12-01
• DOI: 10.1016/s0140-6736(11)61125-2
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Heart Protection Study Collaborative Group; Cholesterol, LDL; Follow-Up Studies; Simvastatin; Hypercholesterolemia; Middle Aged; Adult; Male; Aged; Myocardial Revascularization; Cholesterol; Stroke; Aged, 80 and over; Myocardial Infarction; Neoplasms