Journal article
Subthalamic nucleus deep brain stimulation evokes resonant neural activity
- Abstract:
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Deep brain stimulation is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here we show that deep brain stimulation evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson’s disease), coincides with improved clinical performance, is chronically recordable, and presen...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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- Files:
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(pdf, 260.7KB)
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- Publisher copy:
- 10.1002/ana.25234
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Authors
Funding
+ Australian Government Research Training Program Scholarship
More from this funder
Funding agency for:
Sinclair, NC
+ National Health and Medical Research Council
More from this funder
Funding agency for:
Thevathasan, W
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Annals of Neurology Journal website
- Volume:
- 83
- Issue:
- 5
- Pages:
- 1027-1031
- Publication date:
- 2018-05-04
- Acceptance date:
- 2018-04-16
- DOI:
- EISSN:
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1531-8249
- ISSN:
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0364-5134
- Pubs id:
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pubs:843910
- URN:
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uri:67f343c2-a64d-48f9-9876-dfe69dd7b3e5
- UUID:
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uuid:67f343c2-a64d-48f9-9876-dfe69dd7b3e5
- Local pid:
- pubs:843910
Terms of use
- Copyright holder:
- American Neurological Association
- Copyright date:
- 2018
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use anddistribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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