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Subthalamic nucleus deep brain stimulation evokes resonant neural activity

Abstract:

Deep brain stimulation is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here we show that deep brain stimulation evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson’s disease), coincides with improved clinical performance, is chronically recordable, and presen...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/ana.25234

Authors


Sinclair, NC More by this author
McDermott, HJ More by this author
Bulluss, KJ More by this author
Fallon, JB More by this author
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Funding agency for:
Thevathasan, W
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*Grant Number Example*
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Publisher:
Wiley Publisher's website
Journal:
Annals of Neurology Journal website
Volume:
83
Issue:
5
Pages:
1027-1031
Publication date:
2018-05-04
Acceptance date:
2018-04-16
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
Pubs id:
pubs:843910
URN:
uri:67f343c2-a64d-48f9-9876-dfe69dd7b3e5
UUID:
uuid:67f343c2-a64d-48f9-9876-dfe69dd7b3e5
Local pid:
pubs:843910

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