The role of cell proliferation and crypt fission in adenoma aggressiveness: a comparison of ileoanal pouch and rectal adenomas in familial adenomatous polyposis.

Journal article

AIM: In patients with familial adenomatous polyposis (FAP), ileoanal pouch cancer is rare whereas rectal cancer is common, despite polyp initiation at the two sites being similar at the molecular level. This study investigated whether the disparity in adenoma aggressiveness reflects underlying differences in histogenesis. METHOD: Normal mucosal biopsies and 2-3 mm adenomas from patients with FAP were dissected into individual crypts. Crypt area, morphology, fission and mitoses were analysed ...

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Authors: Will, O; Deheragoda, M; Phillips, R; Clark, S; Tomlinson, I

• Publication status: Published
• Journal: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
• Volume: 13
• Issue: 4
• Pages: 387-392
• Publication date: 2011-04-01
• DOI: 10.1111/j.1463-1318.2009.02159.x
• EISSN: 1463-1318
• ISSN: 1462-8910
• Language: English
• Keywords: Humans; Intestinal Mucosa; Intestinal Polyps; Colonic Pouches; Tumor Suppressor Protein p53; Disease Progression; Cell Proliferation; beta Catenin; Adenomatous Polyps; Adenoma; Adenomatous Polyposis Coli; Biopsy; Rectal Neoplasms