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The role of cell proliferation and crypt fission in adenoma aggressiveness: a comparison of ileoanal pouch and rectal adenomas in familial adenomatous polyposis.

Abstract:

AIM: In patients with familial adenomatous polyposis (FAP), ileoanal pouch cancer is rare whereas rectal cancer is common, despite polyp initiation at the two sites being similar at the molecular level. This study investigated whether the disparity in adenoma aggressiveness reflects underlying differences in histogenesis. METHOD: Normal mucosal biopsies and 2-3 mm adenomas from patients with FAP were dissected into individual crypts. Crypt area, morphology, fission and mitoses were analysed ...

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Publication status:
Published

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Journal:
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland More from this journal
Volume:
13
Issue:
4
Pages:
387-392
Publication date:
2011-04-01
DOI:
EISSN:
1463-1318
ISSN:
1462-8910
Language:
English
Keywords:
Pubs id:
pubs:72284
UUID:
uuid:67e9cc9f-ff92-4e49-88b8-53680402c472
Local pid:
pubs:72284
Source identifiers:
72284
Deposit date:
2012-12-19

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