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Journal article

The Pak1 signalling pathway in cardiac disease: from mechanistic study to therapeutic exploration.

Abstract:

p21-activated kinase 1 (Pak1) is a member of the highly conserved family of serine/threonine protein kinases regulated by Ras-related small G-proteins, Cdc42/Rac1. It has been previously demonstrated to be involved in cardiac protection. Based on recent studies, this review assembles an overview of the role of Pak1 in cardiac diseases including disrupted Ca(2+) homoeostasis related cardiac arrhythmias, β-adrenergic stress and pressure overload-induced hypertrophy, and ischemia/reperfusion inj...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/bph.13872

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Name:
British Heart Foundation
Grant:
FS/15/16/31477
Publisher:
Wiley
Journal:
British Journal of Pharmacology More from this journal
Volume:
175
Issue:
8
Pages:
1362-1374
Publication date:
2017-06-02
Acceptance date:
2017-05-17
DOI:
ISSN:
1476-5381
Language:
English
Keywords:
Pubs id:
pubs:698579
UUID:
uuid:67e93dee-84c0-4423-a358-c8c9014a439f
Local pid:
pubs:698579
Source identifiers:
698579
Deposit date:
2017-06-12

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