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Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades.

Abstract:
The enantioselective synthesis of heavily decorated spirolactams has been accomplished via an arylative or vinylative allene carbocyclisation cascade. Mediated by silver phosphate, a range of allene-linked pro-nucleophiles and aryl or vinyl iodides were reacted in the presence of catalytic Pd(OAc)2 and chiral bis(oxazoline) ligands to afford the spirolactam products in good yields and high enantio- and diastereoselectivities.
Publication status:
Published

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Publisher copy:
10.1039/c3cc42079e

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Journal:
Chemical Communications
Volume:
49
Issue:
46
Pages:
5265-5267
Publication date:
2013-06-01
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Source identifiers:
401533
Language:
English
Keywords:
Pubs id:
pubs:401533
UUID:
uuid:67e634b0-881d-43cd-aa0a-dd9da8d3cc54
Local pid:
pubs:401533
Deposit date:
2013-11-17

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