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Unlinking chromosome catenanes in vivo by site-specific recombination.

Abstract:

A challenge for chromosome segregation in all domains of life is the formation of catenated progeny chromosomes, which arise during replication as a consequence of the interwound strands of the DNA double helix. Topoisomerases play a key role in DNA unlinking both during and at the completion of replication. Here we report that chromosome unlinking can instead be accomplished by multiple rounds of site-specific recombination. We show that step-wise, site-specific recombination by XerCD-dif or...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7601849

Authors


Journal:
EMBO journal More from this journal
Volume:
26
Issue:
19
Pages:
4228-4238
Publication date:
2007-10-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Language:
English
Keywords:
Pubs id:
pubs:100304
UUID:
uuid:67e61ef6-e573-47d6-a948-f71cbcfff08b
Local pid:
pubs:100304
Source identifiers:
100304
Deposit date:
2012-12-19

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