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Journal article

The chromatin structure of Rous sarcoma proviruses is changed by factors that act in trans in cell hybrids.

Abstract:

In several lines of Rous sarcoma virus (RSV)-transformed rat cells the proviruses are in a configuration typical of active eukaryotic genes. They are sensitive to pancreatic DNase I, with sites hypersensitive to nuclease near the 5' end of the genome, they are close to the nuclear 'cage' and they show a low level of cytosine methylation in CpG doublets. In contrast, in phenotypically untransformed hybrids between these cells and uninfected rat or mouse cells, RSV inactivity is associated with...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
EMBO journal More from this journal
Volume:
4
Issue:
2
Pages:
413-420
Publication date:
1985-02-01
EISSN:
1460-2075
ISSN:
0261-4189
Language:
English
Keywords:
Pubs id:
pubs:1993
UUID:
uuid:67e19d33-0386-4b23-9104-fab2d3eccb01
Local pid:
pubs:1993
Source identifiers:
1993
Deposit date:
2012-12-19

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