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Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke.

Abstract:

Erythropoietin (EPO) is a neuroprotective cytokine in models of ischemic and nervous system injury, where it reduces neuronal apoptosis and inflammatory cytokines and increases neurogenesis and angiogenesis. EPO also improves cognition in healthy volunteers and schizophrenic patients. We studied the effect of EPO administration on the gene-expression profile in the ischemic cortex of rats after cerebral ischemia at early time points (2 and 6 h). EPO treatment up-regulated genes already increa...

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Publisher copy:
10.1073/pnas.1200554109

Authors


Mengozzi, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Erbayraktar, Z More by this author
Gökmen, N More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
24
Pages:
9617-9622
Publication date:
2012-06-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:67dc888d-555d-4fca-a5de-9dbf19ae0dcc
Source identifiers:
470787
Local pid:
pubs:470787

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