Heregulin ameliorates the dystrophic phenotype in mdx mice.

Journal article

Duchenne's muscular dystrophy (DMD) is a fatal neuromuscular disease caused by absence of dystrophin. Utrophin is a chromosome 6-encoded dystrophin-related protein (DRP), sharing functional motifs with dystrophin. Utrophin's ability to compensate for dystrophin during development and when transgenically overexpressed has provided an important impetus for identifying activators of utrophin expression. The utrophin promoter A is transcriptionally regulated in part by heregulin-mediated, extrace...

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Authors: Krag, T; Bogdanovich, S; Jensen, C; Fischer, M; Hansen-Schwartz, J

• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 101
• Issue: 38
• Pages: 13856-13860
• Publication date: 2004-09-01
• DOI: 10.1073/pnas.0405972101
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Muscular Dystrophy, Animal; Injections, Intraperitoneal; Mice; Mice, Inbred mdx; Animals; Neuregulin-1; Utrophin; Phenotype; Male