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Heregulin ameliorates the dystrophic phenotype in mdx mice.

Abstract:

Duchenne's muscular dystrophy (DMD) is a fatal neuromuscular disease caused by absence of dystrophin. Utrophin is a chromosome 6-encoded dystrophin-related protein (DRP), sharing functional motifs with dystrophin. Utrophin's ability to compensate for dystrophin during development and when transgenically overexpressed has provided an important impetus for identifying activators of utrophin expression. The utrophin promoter A is transcriptionally regulated in part by heregulin-mediated, extrace...

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Publisher copy:
10.1073/pnas.0405972101

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
101
Issue:
38
Pages:
13856-13860
Publication date:
2004-09-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:372313
UUID:
uuid:67d7f01f-d0aa-4892-a6fa-7c7ff80012c6
Local pid:
pubs:372313
Source identifiers:
372313
Deposit date:
2013-11-16

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