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Journal article

PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein.

Abstract:

Nuclear foci containing the promyelocytic leukemia protein (PML bodies), which occur in most cells, play a role in tumor suppression. Here, we demonstrate that CHFR, a mitotic checkpoint protein frequently inactivated in human cancers, is a dynamic component of PML bodies. Intermolecular fluorescence resonance energy transfer analysis identified a distinct fraction of CHFR that interacts with PML in living cells. This interaction modulates the nuclear distribution and mobility of CHFR. A tran...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb837

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Nature structural and molecular biology More from this journal
Volume:
11
Issue:
11
Pages:
1114-1121
Publication date:
2004-11-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993

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