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EXCHANGE OF THE VALINE-2-H IN THE BIOSYNTHESIS OF L-DELTA-(ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE

Abstract:

Incubation of [2-2H]-valine with purified ACV synthetase from both Cephalosporium acremonium and Streptomyces clavuligerus produced L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine (ACV), determined by the essentially complete (>95%) loss of deuterium from the α position of the incorporated valine. Incubations with deuterium oxide/water as solvent produced ACV with significant incorporation of deuterium into the valinyl residue. These observations confirm the prior proposal that a single multifun...

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Publication status:
Published

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Authors


BALDWIN, J More by this author
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Journal:
TETRAHEDRON
Volume:
49
Issue:
15
Pages:
3221-3226
Publication date:
1993-04-09
DOI:
ISSN:
0040-4020
URN:
uuid:67ceaeb4-594a-4668-9991-a033cbf68460
Source identifiers:
44102
Local pid:
pubs:44102

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