Application of magnetic field hyperthermia and superparamagnetic iron oxide nanoparticles to HIV-1-specific T-cell cytotoxicity.

Journal article

The latent HIV-1 reservoir remains the major barrier to HIV-1 eradication. Although successful at limiting HIV replication, highly active antiretroviral therapy is unable to cure HIV infection, thus novel therapeutic strategies are needed to eliminate the virus. Magnetic field hyperthermia (MFH) generates thermoablative cytotoxic temperatures in target-cell populations, and has delivered promising outcomes in animal models, as well as in several cancer clinical trials. MFH has been proposed a...

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Authors: Williams, J; Southern, P; Lissina, A; Christian, H; Sewell, A

• Journal: International journal of nanomedicine
• Volume: 8
• Pages: 2543-2554
• Publication date: 2013-01-01
• DOI: 10.2147/ijn.s44013
• EISSN: 1178-2013
• ISSN: 1176-9114
• Language: English
• Keywords: Humans; Cell Survival; T-Lymphocytes, Cytotoxic; Hyperthermia, Induced; Flow Cytometry; HIV-1; Receptors, Antigen, T-Cell; Cells, Cultured; Nanomedicine; Magnetite Nanoparticles; Endocytosis; CD8-Positive T-Lymphocytes; Magnetic Fields; Hot Temperature; Transfection