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Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.

Abstract:

GH has potent effects on adipocyte biology, stimulating lipolysis but also promoting preadipocyte proliferation. In addition, GH, acting through IGF-I, inhibits 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which converts the inactive glucocorticoid, cortisone (E), to active cortisol (F) in adipose tissue. Although F is an essential requirement for adipocyte differentiation, it also inhibits preadipocyte proliferation. We hypothesized that inhibition of 11 beta-HSD1 activity in ...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2002-021894

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Journal:
Journal of clinical endocrinology and metabolism
Volume:
88
Issue:
5
Pages:
2113-2118
Publication date:
2003-05-01
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
Source identifiers:
482108

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