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Kinetoplastid kinetochore proteins KKT2 and KKT3 have unique centromere localization domainsation domains

Abstract:

The kinetochore is the macromolecular protein complex that assembles onto centromeric DNA and binds spindle microtubules. Evolutionarily divergent kinetoplastids have an unconventional set of kinetochore proteins. It remains unknown how kinetochores assemble at centromeres in these organisms. Here, we characterize KKT2 and KKT3 in the kinetoplastid parasite Trypanosoma brucei. In addition to the N-terminal kinase domain and C-terminal divergent polo boxes, these proteins have a central domain...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0001-9597-9458
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
210622/Z/18/Z
Publisher:
Rockefeller University Press
Journal:
Journal of Cell Biology More from this journal
Volume:
220
Issue:
8
Article number:
e202101022
Publication date:
2021-06-03
Acceptance date:
2021-05-12
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Language:
English
Keywords:
Pubs id:
1176202
Local pid:
pubs:1176202
Deposit date:
2021-05-13

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