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Supramolecular iron cylinder with unprecedented DNA binding is a potent cytostatic and apoptotic agent without exhibiting genotoxicity.

Abstract:

The supramolecular iron cylinder, [Fe(2)L(3)]Cl(4) (L = C(25)H(20)N(4)), shows unprecedented DNA binding in vitro, inducing intramolecular DNA coiling and also targeting Y-shaped DNA junctions. We investigated its effects on proliferation and survival in both tumor and normal cell lines. Iron cylinder reduced mitochondrial activity of cultures with potency similar to cisplatin, inhibited the cell cycle, and increased cell death by apoptosis. Associated with this, we observed a lowering of the...

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Publication status:
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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
Journal:
Chemistry and biology More from this journal
Volume:
15
Issue:
12
Pages:
1258-1267
Publication date:
2008-12-01
DOI:
EISSN:
1879-1301
ISSN:
1074-5521
Language:
English
Keywords:
Pubs id:
pubs:155810
UUID:
uuid:67bc9b8b-f5e0-4cea-b6a7-f1963d3cfa9b
Local pid:
pubs:155810
Source identifiers:
155810
Deposit date:
2012-12-19

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