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Journal article

In silico guided reconstruction and analysis of ICAM-1-binding var genes from 1 Plasmodium falciparum

Abstract:

The Plasmodium falciparum variant surface antigen PfEMP1 expressed on the surface of infected erythrocytes is thought to play a major role in the pathology of severe malaria. As the sequence pool of the var genes encoding PfEMP1 expands there are opportunities, despite the high degree of sequence diversity demonstrated by this gene family, to reconstruct full-length var genes from small sequence tags generated from patient isolates. To test whether this is possible we have used a set of recen...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-018-21591-8

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Strategic
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Strategic
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
3282
Publication date:
2018-02-05
Acceptance date:
2018-02-07
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:823120
URN:
uri:67b6c1dc-71d1-4ade-b75e-414459a22da6
UUID:
uuid:67b6c1dc-71d1-4ade-b75e-414459a22da6
Local pid:
pubs:823120

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