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Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum

Abstract:

Dopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response to reward and reward-predicting cues, phasic dopamine activity potentiates the efficacy of corticostriatal synapses on spiny projection neurons (SPNs). Since phasic dopamine activity also encodes other behavioural variables, it is unclear how postsynaptic neurons identify which dopamine event is to induce long-term plasticity. Additionally, it is unknown how phasic dop...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-022-28950-0

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Role:
Author
ORCID:
0000-0002-5924-4865
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Role:
Author
ORCID:
0000-0002-6262-7605
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Role:
Author
ORCID:
0000-0003-0858-6088
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Role:
Author
ORCID:
0000-0003-0037-6932
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Role:
Author
ORCID:
0000-0003-1547-747X
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
13
Issue:
1
Article number:
1296
Publication date:
2022-03-11
Acceptance date:
2022-02-18
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1243436
Local pid:
pubs:1243436
Deposit date:
2022-03-11

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