Journal article
Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.
- Abstract:
-
Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 5.2MB)
-
- Publisher copy:
- 10.1016/j.ccr.2014.03.036
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cancer cell Journal website
- Volume:
- 25
- Issue:
- 6
- Pages:
- 794-808
- Publication date:
- 2014-06-01
- DOI:
- EISSN:
-
1878-3686
- ISSN:
-
1535-6108
- Source identifiers:
-
465943
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:465943
- UUID:
-
uuid:67b3347a-b51c-4a0f-b5b4-741b4f8d5713
- Local pid:
- pubs:465943
- Deposit date:
- 2014-08-22
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2014
- Notes:
- Copyright © 2014 Elsevier Inc. Under Elsevier user license.
- Licence:
- Other
If you are the owner of this record, you can report an update to it here: Report update to this record