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Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Abstract:

Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Cell Press
Journal:
Cancer cell More from this journal
Volume:
25
Issue:
6
Pages:
794-808
Publication date:
2014-06-01
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
Language:
English
Keywords:
Pubs id:
pubs:465943
UUID:
uuid:67b3347a-b51c-4a0f-b5b4-741b4f8d5713
Local pid:
pubs:465943
Source identifiers:
465943
Deposit date:
2014-08-22

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