- Abstract:
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Oxygen plays a central role in cellular metabolism, in both healthy and tumour tissue. The presence and concentration of molecular oxygen in tumours has a substantial effect on both radiotherapy response and tumour evolution, and as a result the oxygen micro-environment is an area of intense research interest. Multi-cellular tumour spheroids closely mimic real avascular tumours, and in particular they exhibit physiologically relevant heterogeneous oxygen distribution. This property has made t...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.1MB)
-
- Publisher copy:
- 10.1098/rsif.2018.0256
-
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- Publisher:
- Royal Society Publisher's website
- Journal:
- Journal of the Royal Society Interface Journal website
- Volume:
- 15
- Issue:
- 145
- Pages:
- Article: 20180256
- Publication date:
- 2018-08-15
- Acceptance date:
- 2018-07-23
- DOI:
- EISSN:
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1742-5662
- ISSN:
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1742-5689
- Pubs id:
-
pubs:892064
- URN:
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uri:67b096d7-f3af-4ee6-8e7c-58e778261407
- UUID:
-
uuid:67b096d7-f3af-4ee6-8e7c-58e778261407
- Local pid:
- pubs:892064
- Copyright holder:
- Grimes et al.
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 The Authors.
Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Journal article
Oxygen diffusion in ellipsoidal tumour spheroids
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Queen's University Belfast
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