Journal article icon

Journal article

Oxygen diffusion in ellipsoidal tumour spheroids

Abstract:

Oxygen plays a central role in cellular metabolism, in both healthy and tumour tissue. The presence and concentration of molecular oxygen in tumours has a substantial effect on both radiotherapy response and tumour evolution, and as a result the oxygen micro-environment is an area of intense research interest. Multi-cellular tumour spheroids closely mimic real avascular tumours, and in particular they exhibit physiologically relevant heterogeneous oxygen distribution. This property has made t...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1098/rsif.2018.0256

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More from this funder
Funding agency for:
Grimes, DR
Queen's University Belfast More from this funder
Publisher:
Royal Society Publisher's website
Journal:
Journal of the Royal Society Interface Journal website
Volume:
15
Issue:
145
Pages:
Article: 20180256
Publication date:
2018-08-15
Acceptance date:
2018-07-23
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
Pubs id:
pubs:892064
URN:
uri:67b096d7-f3af-4ee6-8e7c-58e778261407
UUID:
uuid:67b096d7-f3af-4ee6-8e7c-58e778261407
Local pid:
pubs:892064

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP