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Differences in DNA fragmentation following transient cerebral or decapitation ischemia in rats.

Abstract:

The time course of appearance of cells with DNA damage was studied in rats following transient severe forebrain ischemia. This DNA damage could be detected by in situ end-labeling on brain sections. The breaks in DNA appeared selectively by day 1 in the striatum and later in the CA1 region of the hippocampus. It was possible by double labeling to show that there was no DNA damage in astrocytes. The DNA breaks consisted of laddered DNA fragments indicative of an ordered apoptotic type of inter...

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Publication status:
Published

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Publisher copy:
10.1038/jcbfm.1995.94

Authors


MacManus, JP More by this author
Preston, E More by this author
Rasquinha, I More by this author
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Journal:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume:
15
Issue:
5
Pages:
728-737
Publication date:
1995-09-05
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
URN:
uuid:67a42bcc-474c-473d-92de-7d289d15d54d
Source identifiers:
80181
Local pid:
pubs:80181

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