- Abstract:
-
Mutations in splicing factor genes (SF3B1, SRSF2, U2AF1 and ZRSR2) are frequently found in patients with myelodysplastic syndromes (MDS), suggesting that aberrant spliceosome function plays a key role in the pathogenesis of MDS. Splicing factor mutations have been shown to result in aberrant splicing of many downstream target genes. Recent functional studies have begun to characterize the splicing dysfunction in MDS, identifying some key aberrantly spliced genes that are implicated in disease...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manucript
- Files:
-
-
(eps, 8.3mb)
-
(pdf, 756.3kb)
-
- Publisher copy:
- 10.1016/j.jbior.2017.09.008
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Advances in Biological Regulation Journal website
- Volume:
- 67
- Pages:
- 13-29
- Publication date:
- 2017-09-22
- Acceptance date:
- 2017-09-21
- DOI:
- EISSN:
-
2212-4934
- ISSN:
-
2212-4926
- Pubs id:
-
pubs:734708
- URN:
-
uri:67a3f5c0-17e0-4aaf-9b39-0283832831af
- UUID:
-
uuid:67a3f5c0-17e0-4aaf-9b39-0283832831af
- Local pid:
- pubs:734708
- Language:
- English
- Keywords:
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2017
- Notes:
- © 2017 Elsevier Ltd. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.jbior.2017.09.008
Journal article
Splicing factor mutations in the myelodysplastic syndromes: target genes and therapeutic approaches
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