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Splicing factor mutations in the myelodysplastic syndromes: target genes and therapeutic approaches

Abstract:

Mutations in splicing factor genes (SF3B1, SRSF2, U2AF1 and ZRSR2) are frequently found in patients with myelodysplastic syndromes (MDS), suggesting that aberrant spliceosome function plays a key role in the pathogenesis of MDS. Splicing factor mutations have been shown to result in aberrant splicing of many downstream target genes. Recent functional studies have begun to characterize the splicing dysfunction in MDS, identifying some key aberrantly spliced genes that are implicated in disease...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manucript

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Publisher copy:
10.1016/j.jbior.2017.09.008

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
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Publisher:
Elsevier Publisher's website
Journal:
Advances in Biological Regulation Journal website
Volume:
67
Pages:
13-29
Publication date:
2017-09-22
Acceptance date:
2017-09-21
DOI:
EISSN:
2212-4934
ISSN:
2212-4926
Pubs id:
pubs:734708
URN:
uri:67a3f5c0-17e0-4aaf-9b39-0283832831af
UUID:
uuid:67a3f5c0-17e0-4aaf-9b39-0283832831af
Local pid:
pubs:734708

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