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Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.

Abstract:

To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor-activating protein 2beta (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabete...

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Publication status:
Published

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Publisher copy:
10.1007/s10038-005-0253-9

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Journal:
Journal of human genetics More from this journal
Volume:
50
Issue:
6
Pages:
283-292
Publication date:
2005-01-01
DOI:
EISSN:
1435-232X
ISSN:
1434-5161

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