Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.

Journal article

To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor-activating protein 2beta (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabete...

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Authors: Maeda, S; Tsukada, S; Kanazawa, A; Sekine, A; Tsunoda, T

• Publication status: Published
• Journal: Journal of human genetics
• Volume: 50
• Issue: 6
• Pages: 283-292
• Publication date: 2005-01-01
• DOI: 10.1007/s10038-005-0253-9
• EISSN: 1435-232X
• ISSN: 1434-5161
• Language: English
• Keywords: Japan; Great Britain; DNA-Binding Proteins; Polymorphism, Single Nucleotide; Transcription Factors; Linkage Disequilibrium; Transcription Factor AP-2; Reverse Transcriptase Polymerase Chain Reaction; Gene Expression Profiling; Genetic Predisposition to Disease; Genotype; DNA Primers; Regression Analysis; Sequence Analysis, DNA; Base Sequence; Molecular Sequence Data; Humans; Diabetes Mellitus, Type 2; Haplotypes; Odds Ratio