Journal article
Simultaneous Bayesian estimation of alignment and phylogeny under a joint model of protein sequence and structure.
- Abstract:
-
For sequences that are highly divergent, there is often insufficient information to infer accurate alignments, and phylogenetic uncertainty may be high. One way to address this issue is to make use of protein structural information, since structures generally diverge more slowly than sequences. In this work, we extend a recently developed stochastic model of pairwise structural evolution to multiple structures on a tree, analytically integrating over ancestral structures to permit efficient l...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/molbev/msu184
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Authors
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Molecular biology and evolution
- Volume:
- 31
- Issue:
- 9
- Pages:
- 2251-2266
- Publication date:
- 2014-09-01
- DOI:
- EISSN:
-
1537-1719
- ISSN:
-
0737-4038
- Source identifiers:
-
469544
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:469544
- UUID:
-
uuid:67a27df9-d112-436f-a460-63a0d6c6c1bf
- Local pid:
- pubs:469544
- Deposit date:
- 2014-10-15
Terms of use
- Copyright date:
- 2014
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