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Simultaneous Bayesian estimation of alignment and phylogeny under a joint model of protein sequence and structure.

Abstract:

For sequences that are highly divergent, there is often insufficient information to infer accurate alignments, and phylogenetic uncertainty may be high. One way to address this issue is to make use of protein structural information, since structures generally diverge more slowly than sequences. In this work, we extend a recently developed stochastic model of pairwise structural evolution to multiple structures on a tree, analytically integrating over ancestral structures to permit efficient l...

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Publication status:
Published

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Publisher copy:
10.1093/molbev/msu184

Authors


Herman, JL More by this author
Challis, CJ More by this author
Novák, Á More by this author
Schmidler, SC More by this author
Publisher:
Oxford University Press
Journal:
Molecular biology and evolution
Volume:
31
Issue:
9
Pages:
2251-2266
Publication date:
2014-09-05
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
URN:
uuid:67a27df9-d112-436f-a460-63a0d6c6c1bf
Source identifiers:
469544
Local pid:
pubs:469544

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