Centrioles regulate centrosome size by controlling the rate of Cnn incorporation into the PCM.

Journal article

BACKGROUND: centrosomes are major microtubule organizing centers in animal cells, and they comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Centrosome size is tightly regulated during the cell cycle, and it has recently been shown that the two centrosomes in certain stem cells are often asymmetric in size. There is compelling evidence that centrioles influence centrosome size, but how centrosome size is set remains mysterious. RESULTS: we show that the c...

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Authors: Conduit, P; Brunk, K; Dobbelaere, J; Dix, C; Lucas, E

• Publication status: Published
• Journal: Current biology : CB
• Volume: 20
• Issue: 24
• Pages: 2178-2186
• Publication date: 2010-12-01
• DOI: 10.1016/j.cub.2010.11.011
• EISSN: 1879-0445
• ISSN: 0960-9822
• Language: English
• Keywords: Drosophila melanogaster; Recombinant Fusion Proteins; Centrioles; Centrosome; Humans; Drosophila Proteins; Homeodomain Proteins; Animals