Understanding typhoid disease; a controlled human infection model of typhoid fever
Typhoid disease, caused by infection with S. Typhi, is a significant cause of mortality and morbidity in resource–poor countries. Efforts have been made to generate a new generation of vaccines that are efficacious and can be given to infants, but have been hindered by a poor understanding of the protective immune response to S. Typhi infection, and in particular by the absence of a correlate of protection.
Controlled human infection st...Expand abstract
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- University of Oxford
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- Claire Waddington
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