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Shigella flexneri Spa15 crystal structure verified in solution by double electron electron resonance.

Abstract:

Shigella flexneri Spa15 is a chaperone of the type 3 secretion system, which binds a number of effectors to ensure their stabilization prior to secretion. One of these effectors is IpgB1, a mimic of the human Ras-like Rho guanosine triphosphatase RhoG. In this study, Spa15 alone and in complex with IpgB1 has been studied by double electron electron resonance, an experiment that gives distance information showing the spacial separation of attached spin labels. This distance is explained by det...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2010.10.053

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Role:
Author
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Journal:
Journal of molecular biology
Volume:
405
Issue:
2
Pages:
427-435
Publication date:
2011-01-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:679224df-426c-4600-950b-6c5439671f2a
Source identifiers:
97248
Local pid:
pubs:97248

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