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Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia

Abstract:

Genome sequences of 247 Plasmodium falciparum isolates collected in The Gambia in 2008 and 2014 were analysed to identify changes possibly related to the scale-up of antimalarial interventions that occurred during this period. Overall, there were 15 regions across the genomes with signatures of positive selection. Five of these were sweeps around known drug resistance and antigenic loci. Signatures at antigenic loci such as thrombospodin related adhesive protein (Pftrap) were most frequent in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0003-4478-3601
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Role:
Author
ORCID:
0000-0001-8633-9221
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Name:
Medical Research Council (MRC)
Grant:
MC_EX_MR/K02440X/1
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Name:
Medical Research Council
Grant:
MC_EX_MR/K02440X/1
MC_UP_A900_1119
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
8
Issue:
2018
Article number:
9687
Publication date:
2018-06-26
Acceptance date:
2018-06-14
DOI:
ISSN:
2045-2322
Pmid:
29946063
Language:
English
Keywords:
Pubs id:
pubs:1037108
UUID:
uuid:678fbca6-a959-4eeb-892a-b812e5535c09
Local pid:
pubs:1037108
Source identifiers:
1037108
Deposit date:
2019-09-06

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