Dimenhydrinate in children with infectious gastroenteritis: a prospective, RCT.

Journal article

OBJECTIVE: Vomiting is a common symptom in children with infectious gastroenteritis. It contributes to fluid loss and is a limiting factor for oral rehydration therapy. Dimenhydrinate has traditionally been used for children with gastroenteritis in countries such as Canada and Germany. We investigated the efficacy and safety of dimenhydrinate in children with acute gastroenteritis. METHODS: We performed a prospective, randomized, placebo-controlled, multicenter trial. We randomly assigned 24...

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Authors: Uhlig, U; Pfeil, N; Gelbrich, G; Spranger, C; Syrbe, S

• Journal: Pediatrics
• Volume: 124
• Issue: 4
• Pages: e622-e632
• Publication date: 2009-10-01
• DOI: 10.1542/peds.2008-1650
• EISSN: 1098-4275
• ISSN: 0031-4005
• Language: English
• Keywords: Child; Child, Preschool; Suppositories; Drug Administration Schedule; Treatment Outcome; Dehydration; Prospective Studies; Statistics, Nonparametric; Vomiting; Confidence Intervals; Fluid Therapy; Reference Values; Female; Male; Probability; Risk Assessment; Follow-Up Studies; Severity of Illness Index; Double-Blind Method; Dimenhydrinate; Dose-Response Relationship, Drug; Infant; Antiemetics; Gastroenteritis; Acute Disease; Humans