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BRN2 is a non-canonical melanoma tumor-suppressor

Abstract:

While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling is not well understood. The POU domain transcription factor BRN2 is a key regulator of melanoma invasion, yet its role in melanoma initiation remains unknown. Here, in a BrafV600E PtenF/+ context, we show that BRN2 haplo-insufficiency promotes mel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-23973-5

Authors


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Name:
Ludwig Institute for Cancer Research
Grant:
24/02/2017
Publisher:
Nature Research
Journal:
Nature Communications More from this journal
Volume:
12
Issue:
1
Article number:
3707
Publication date:
2021-06-17
Acceptance date:
2021-05-27
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1179274
Local pid:
pubs:1179274
Deposit date:
2021-05-28

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