Journal article
BRN2 is a non-canonical melanoma tumor-suppressor
- Abstract:
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While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling is not well understood. The POU domain transcription factor BRN2 is a key regulator of melanoma invasion, yet its role in melanoma initiation remains unknown. Here, in a BrafV600E PtenF/+ context, we show that BRN2 haplo-insufficiency promotes mel...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Supplementary materials, 21.1MB)
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(Version of record, 1.9MB)
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- Publisher copy:
- 10.1038/s41467-021-23973-5
Authors
Funding
Bibliographic Details
- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 12
- Issue:
- 1
- Article number:
- 3707
- Publication date:
- 2021-06-17
- Acceptance date:
- 2021-05-27
- DOI:
- EISSN:
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2041-1723
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1179274
- Local pid:
- pubs:1179274
- Deposit date:
- 2021-05-28
Terms of use
- Copyright holder:
- Hamm et al.
- Copyright date:
- 2021
- Rights statement:
- © The Authors 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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