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In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis

Abstract:

Universal drug susceptibility testing (DST) for tuberculosis is a major goal of the END TB strategy. PCR-based molecular diagnostic tests have been instrumental in increasing DST globally and several assays have now been endorsed by the World Health Organization (WHO) for use in the diagnosis of drug resistance. These endorsed assays, however, each interrogate a limited number of mutations associated with resistance, potentially limiting their sensitivity compared to sequencing-based methods....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-022-21025-6

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0003-0421-9264
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Name:
Wellcome Trust
Grant:
214560/Z/18/Z
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
12
Article number:
17741
Publication date:
2022-10-22
Acceptance date:
2022-09-21
DOI:
EISSN:
2045-2322
Pmid:
36273016

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