Rat chromosome 9 bears a major susceptibility locus for IgE response.

Journal article

Injection of Brown Norway (BN) rats with gold salts provides a model to analyze the genetic control of the IgE response. A cohort of F2 progeny of susceptible BN and resistant LEW strains has been studied to carry out a genome-wide search for loci controlling the IgE response. Genome scanning identified two previously described loci, Atps1 and Atps2, and a new locus, Atps3. Atps1 linked to the MHC and Atps2 linked to the cytokine gene cluster that included the IL-4 region have been previously...

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Authors: Mas, M; Subra, J; Lagrange, D; Pilipenko-Appolinaire, S; Kermarrec, N

• Publication status: Published
• Journal: European journal of immunology
• Volume: 30
• Issue: 6
• Pages: 1698-1705
• Publication date: 2000-06-01
• DOI: 10.1002/1521-4141(200006)30:6<1698::aid-immu1698>3.0.co;2-f
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Propanols; Dimercaprol; Male; Rats; Female; Quantitative Trait, Heritable; Rats, Inbred Lew; Immunoglobulin E; Rats, Inbred BN; Sulfhydryl Compounds; Chromosome Mapping; Organogold Compounds; Organometallic Compounds; Animals