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The effects of mutational processes and selection on driver mutations across cancer types

Abstract:

Epidemiological evidence has long associated environmental mutagens with increased cancer risk. However, links between specific mutation-causing processes and the acquisition of individual driver mutations have remained obscure. Here we have used public cancer sequencing data from 11,336 cancers of various types to infer the independent effects of mutation and selection on the set of driver mutations in a cancer type. First, we detect associations between a range of mutational processes, incl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-04208-6

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Funding agency for:
Schuster-Boeckler, P
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Article number:
1857
Publication date:
2018-05-10
Acceptance date:
2018-04-11
DOI:
ISSN:
2041-1723
Source identifiers:
840532
Pubs id:
pubs:840532
UUID:
uuid:67849904-c14e-461d-80c8-6a80f717ed6c
Local pid:
pubs:840532
Deposit date:
2018-04-17

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