Journal article
The effects of mutational processes and selection on driver mutations across cancer types
- Abstract:
-
Epidemiological evidence has long associated environmental mutagens with increased cancer risk. However, links between specific mutation-causing processes and the acquisition of individual driver mutations have remained obscure. Here we have used public cancer sequencing data from 11,336 cancers of various types to infer the independent effects of mutation and selection on the set of driver mutations in a cancer type. First, we detect associations between a range of mutational processes, incl...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Article number:
- 1857
- Publication date:
- 2018-05-10
- Acceptance date:
- 2018-04-11
- DOI:
- ISSN:
-
2041-1723
Item Description
- Pubs id:
-
pubs:840532
- UUID:
-
uuid:67849904-c14e-461d-80c8-6a80f717ed6c
- Local pid:
- pubs:840532
- Source identifiers:
-
840532
- Deposit date:
- 2018-04-17
Terms of use
- Copyright holder:
- Temko et al
- Copyright date:
- 2018
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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