Journal article
Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies
- Abstract:
-
BACKGROUND: Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite depends on an interaction between the Duffy antigen receptor for chemokines (DARC) and region II of the parasite's Duffy-binding protein (PvDBP_RII). Naturally acquired binding-inhibitory antibodies against this interaction associate with clinical immunity, but it is unknown whether these responses can be induced by human vac...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ European Malaria Vaccine Development Association
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Funding agency for:
de Cassan, S
Grant:
LSHP-CT-2007-037506
+ National Health and Medical Research Council
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Funding agency for:
McCarthy, J
Grant:
1041802
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Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- JCI Insight Journal website
- Volume:
- 2
- Issue:
- 12
- Pages:
- e93683
- Publication date:
- 2017-06-15
- Acceptance date:
- 2017-05-16
- DOI:
- ISSN:
-
2379-3708
- Source identifiers:
-
700622
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:700622
- UUID:
-
uuid:67835a07-9102-4b18-abb1-7bfe5670f3c5
- Local pid:
- pubs:700622
- Deposit date:
- 2017-06-24
Terms of use
- Copyright holder:
- American Society for Clinical Investigation
- Copyright date:
- 2017
- Notes:
-
This work is licensed under
the Creative Commons Attribution
4.0 International License. To view
a copy of this license, visit http://
creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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