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Journal article

Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies

Abstract:

BACKGROUND: Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite depends on an interaction between the Duffy antigen receptor for chemokines (DARC) and region II of the parasite's Duffy-binding protein (PvDBP_RII). Naturally acquired binding-inhibitory antibodies against this interaction associate with clinical immunity, but it is unknown whether these responses can be induced by human vac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.93683

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Funding agency for:
Rawlinson, T
Grant:
108734/Z/15/Z
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Funding agency for:
Llewellyn, D
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Funding agency for:
de Cassan, S
Grant:
LSHP-CT-2007-037506
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Funding agency for:
Otto, T
Grant:
WT 098051
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Funding agency for:
McCarthy, J
Grant:
1041802
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
2
Issue:
12
Pages:
e93683
Publication date:
2017-06-15
Acceptance date:
2017-05-16
DOI:
ISSN:
2379-3708
Source identifiers:
700622
Language:
English
Keywords:
Pubs id:
pubs:700622
UUID:
uuid:67835a07-9102-4b18-abb1-7bfe5670f3c5
Local pid:
pubs:700622
Deposit date:
2017-06-24

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