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Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays.

Abstract:

Natural immunity to malaria is characterized by low level CD4 T cell reactivity detected by either lymphoproliferation or IFN-gamma secretion. Here we show a doubling in the detection rate of responders to the carboxyl terminus of circumsporozoite protein (CS) of Plasmodium falciparum by employing three T cell assays simultaneously: rapid IFN-gamma secretion (ex vivo ELISPOT), IFN-gamma secretion after reactivation of memory T cells and expansion in vitro (cultured ELISPOT), and lymphoprolife...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.167.8.4729

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Journal:
Journal of Immunology More from this journal
Volume:
167
Issue:
8
Pages:
4729-4737
Publication date:
2001-10-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767

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