Linkage analysis of chromosome 2q in osteoarthritis.

Journal article

BACKGROUND: In independent linkage studies chromosome 2q11-q24 and chromosome 2q23-35 have previously been implicated as regions potentially harbouring susceptibility loci for osteoarthritis (OA). OBJECTIVE: To test chromosome 2q for linkage to idiopathic osteoarthritis. METHODS: Using a cohort of 481 OA families that each contained at least one affected sibling pair with severe end-stage disease (ascertained by hip or knee joint replacement surgery), we conducted a linkage analysis of chrom...

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Authors: Loughlin, J; Mustafa, Z; Smith, A; Irven, C; Carr, A

• Publication status: Published
• Journal: Rheumatology (Oxford, England)
• Volume: 39
• Issue: 4
• Pages: 377-381
• Publication date: 2000-04-01
• DOI: 10.1093/rheumatology/39.4.377
• EISSN: 1462-0332
• ISSN: 1462-0324
• Language: English
• Keywords: Female; Humans; Genetic Predisposition to Disease; Genetic Linkage; Osteoarthritis; Cohort Studies; Middle Aged; Knee Joint; Male; Severity of Illness Index; Aged; Pedigree; Adult; Chromosomes, Human, Pair 2