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An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion

Abstract:

Abstract The generation of diversity and plasticity of transcriptional programs are key components of effective vertebrate immune responses. The role of Alternative Splicing has been recognized, but it is underappreciated and poorly understood as a critical mechanism for the regulation and fine-tuning of physiological immune responses. Here we report the generation of loss-of-function phenotypes for a large collection of genes known or predicted to be involved in the splicing reaction and the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-6506-7829
More by this author
Role:
Author
ORCID:
0000-0001-6008-6852
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Role:
Author
ORCID:
0000-0002-5506-0233
Publisher:
Public Library of Science
Journal:
PloS one More from this journal
Issue:
5
Publication date:
2011-01-01
Acceptance date:
2011-04-18
DOI:
ISSN:
1932-6203
Pmid:
21611201

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