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Deficiency of a subset of T-cells with immunoregulatory properties in sarcoidosis.

Abstract:

BACKGROUND: Sarcoidosis is a multisystem disorder that predominantly involves the lungs, characterised by a T-helper 1 (Th1) biased CD4-positive T-cell response and granuloma formation, for which the explanation is unknown. A newly identified subset of T-cells with immunoregulatory functions, CD1d-restricted natural-killer T (NKT) cells, has been shown to protect against disorders with increased CD4-positive Th1 responses in animals. We explored whether abnormalities in these cells are implic...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
Journal:
Lancet (London, England) More from this journal
Volume:
365
Issue:
9464
Pages:
1062-1072
Publication date:
2005-03-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Language:
English
Keywords:
Pubs id:
pubs:29640
UUID:
uuid:67735da1-1965-400f-8687-80c2f164e933
Local pid:
pubs:29640
Source identifiers:
29640
Deposit date:
2012-12-19

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