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An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.

Abstract:

The induction of broadly HIV-1 neutralizing antibodies (bNAbs) by vaccination is challenging, but understanding how a subset of HIV-infected individuals (elite neutralizers) develops bNAbs may guide immunization strategies. Here, we describe the isolation and characterization of the bNAb ACS202 from an elite neutralizer that recognizes a new, trimer-specific and cleavage-dependent epitope at the gp120-gp41 interface, involving the glycan N88 and the gp41 fusion peptide. In addition, an Env tr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nmicrobiol.2016.199

Authors


van Gils, MJ More by this author
van den Kerkhof, TLGM More by this author
Ozorowski, G More by this author
Cottrell, CA More by this author
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Netherlands National Institute for Public Health and the Environment More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
2
Pages:
16199
Publication date:
2016-11-05
Acceptance date:
2016-09-09
DOI:
ISSN:
2058-5276
Pubs id:
pubs:661346
URN:
uri:6771b7f2-cab8-44a5-a478-fdb6b9568063
UUID:
uuid:6771b7f2-cab8-44a5-a478-fdb6b9568063
Local pid:
pubs:661346
Language:
English
Keywords:

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