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An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.

Abstract:

The induction of broadly HIV-1 neutralizing antibodies (bNAbs) by vaccination is challenging, but understanding how a subset of HIV-infected individuals (elite neutralizers) develops bNAbs may guide immunization strategies. Here, we describe the isolation and characterization of the bNAb ACS202 from an elite neutralizer that recognizes a new, trimer-specific and cleavage-dependent epitope at the gp120-gp41 interface, involving the glycan N88 and the gp41 fusion peptide. In addition, an Env tr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
International AIDS Vaccine Initiative
Grant:
SFP1849
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Name:
European Research Council
Grant:
ERC-StG-2011-280829-SHEV
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Name:
Netherlands Organization for Scientific Research
Grant:
918.66.628
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Name:
European Molecular Biology Organization
Grant:
ASTF 260-2013
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Name:
Dutch Aids Fonds
Grant:
2012041
Publisher:
Nature Publishing Group
Journal:
Nature Microbiology More from this journal
Volume:
2
Pages:
16199
Publication date:
2016-11-01
Acceptance date:
2016-09-09
DOI:
ISSN:
2058-5276
Language:
English
Keywords:
Pubs id:
pubs:661346
UUID:
uuid:6771b7f2-cab8-44a5-a478-fdb6b9568063
Local pid:
pubs:661346
Source identifiers:
661346
Deposit date:
2016-12-07

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