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Journal article

Defining pre-symptomatic amyotrophic lateral sclerosis

Abstract:

Successful treatment of neurodegenerative disease may hinge on early therapeutic intervention. This requires an understanding of early/pre-symptomatic disease, a need that is underscored by advances in antisense oligonucleotide, and viral-vector-based gene therapies. In amyotrophic lateral sclerosis (ALS), the study of pre-symptomatic disease requires a cohesive conceptual framework for describing this phase of disease. Informed by the literature in other neurodegenerative diseases and extens...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1080/21678421.2019.1587634

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0003-0267-3180
Publisher:
Taylor and Francis Publisher's website
Journal:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Journal website
Volume:
20
Issue:
5-6
Pages:
303-309
Publication date:
2019-03-20
Acceptance date:
2019-02-17
DOI:
EISSN:
2167-9223
ISSN:
2167-8421
Language:
English
Keywords:
Pubs id:
pubs:974353
UUID:
uuid:676c7533-c635-4bcb-8321-6f02f2225c65
Local pid:
pubs:974353
Source identifiers:
974353
Deposit date:
2019-02-18

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