CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma.

Journal article

BACKGROUND: Renal cell carcinoma (RCC) is histopathologically heterogeneous with clear cell and papillary the most common subtypes. The most frequent molecular abnormality in clear cell RCC is VHL inactivation but promoter methylation of tumour suppressor genes is common in both subtypes of RCC. To investigate whether RCC CpG methylation status was influenced by histopathology and VHL status we performed high-throughput epigenetic profiling using the Illumina Goldengate Methylation Array in 6...

Expand abstract

Authors: McRonald, F; Morris, MR; Gentle, D; Winchester, L; Baban, D

• Publication status: Published
• Journal: Molecular cancer
• Volume: 8
• Issue: 1
• Pages: 31
• Publication date: 2009-01-01
• DOI: 10.1186/1476-4598-8-31
• EISSN: 1476-4598
• ISSN: 1476-4598
• Language: English
• Keywords: Epigenesis, Genetic; Cluster Analysis; Aged; von Hippel-Lindau Disease; Kidney Neoplasms; Humans; DNA Methylation; Carcinoma, Renal Cell; Poisson Distribution; Middle Aged; Reproducibility of Results; Statistics, Nonparametric; CpG Islands; Adult; Gene Regulatory Networks