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Size and charge characteristics of the protein leak in dengue shock syndrome.

Abstract:

BACKGROUND: he mechanism underlying the transient vascular leak syndrome of dengue hemorrhagic fever (DHF) is unknown. We aimed to determine whether molecular size and charge selectivity, which help restrict plasma proteins within the intravascular space, are altered in patients with DHF and whether a disturbance of the anionic glycosaminoglycan (GAG) layer on the luminal endothelial surface contributes to disease pathogenesis. METHODS: We measured serial plasma levels and fractional clearan...

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Publication status:
Published

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Publisher copy:
10.1086/422754

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Journal:
The Journal of infectious diseases
Volume:
190
Issue:
4
Pages:
810-818
Publication date:
2004-08-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:6765936f-9342-44cb-a050-c920470e16c3
Source identifiers:
32793
Local pid:
pubs:32793

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