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Are dominant strictures in primary sclerosing cholangitis a risk factor for cholangiocarcinoma?

Abstract:

Cholangiocarcinoma is a devastating, unpredictable complication of large duct primary sclerosing cholangitis (PSC), which occurs in 5-15% of patients. The aim of this review is to discuss whether dominant strictures (DS) occurring in the larger bile ducts in PSC are a risk factor for the development of cholangiocarcinoma.The development of DS is related to specific genetic polymorphisms affecting the innate immune system and the microbiome. In a recent study, the mean survival of PSC patients...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s11901-017-0341-2

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Springer Verlag Publisher's website
Journal:
Current Hepatology Reports Journal website
Volume:
16
Issue:
2
Pages:
124-129
Publication date:
2017-04-27
Acceptance date:
2017-01-01
DOI:
EISSN:
2195-9595
ISSN:
2195-9595
Pmid:
28706774
Language:
English
Keywords:
Pubs id:
pubs:709418
UUID:
uuid:6762766a-84ac-4fb0-af0c-da3f19f1cdff
Local pid:
pubs:709418
Deposit date:
2018-03-15

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