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Genome-wide trans-ethnic meta-analysis identifies seven genetic loci influencing erythrocyte traits and a role for RBPMS in erythropoiesis

Abstract:

Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African ancestries using a Bayesian approach to account for heterogeneity in allelic effects and variation in the structure of linkage disequilibrium between ethnicities. We identified seven loci for erythrocyte traits including a locus (RBPMS/GTF2E2) associ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.ajhg.2016.11.016

Authors


van Rooij, FJ More by this author
Trompet, S More by this author
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Journal:
American Journal of Human Genetics
Volume:
100
Issue:
1
Pages:
51-63
Publication date:
2017-01-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Pubs id:
pubs:667192
URN:
uri:6761b718-3672-43af-b27d-d0237744cff1
UUID:
uuid:6761b718-3672-43af-b27d-d0237744cff1
Local pid:
pubs:667192

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