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A common sequence motif associated with recombination hot spots and genome instability in humans.

Abstract:

In humans, most meiotic crossover events are clustered into short regions of the genome known as recombination hot spots. We have previously identified DNA motifs that are enriched in hot spots, particularly the 7-mer CCTCCCT. Here we use the increased hot-spot resolution afforded by the Phase 2 HapMap and novel search methods to identify an extended family of motifs based around the degenerate 13-mer CCNCCNTNNCCNC, which is critical in recruiting crossover events to at least 40% of all human...

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Publisher copy:
10.1038/ng.213

Authors


Freeman, C More by this author
Donnelly, P More by this author
Journal:
Nature genetics
Volume:
40
Issue:
9
Pages:
1124-1129
Publication date:
2008-09-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:675e2bef-9d9f-4166-897c-063b83bad350
Source identifiers:
103196
Local pid:
pubs:103196

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